Relevance for Human Health

• Mode of Action

 

2017

 

• A quantitative weight of evidence assessment of confidence in modes-of-action and their human relevance

By Dekant W, Bridges J and Scialli A R. Regulatory Toxicology and Pharmacology. Volume 90, November 2017, Pages 51-71.

 

• Biological relevance of effects following chronic administration of octamethylcyclotetrasiloxane (D4) in Fischer 344 rats

By Dekant W, Scialli A R, Plotzke K and Klaunig J E. Toxicology Letters. Volume 279, Supplement 1, 20 October 2017, Pages 42-53.

 

• Risk Assessment

 

2017

 

• A global human health risk assessment for octamethylcyclotetrasiloxane (D4)

By Gentry R, Franzen A, van Landingham C, Greene T and Plotzke K. Toxicology Letters. Volume 279, Supplement 1, 20 October 2017, Pages 23-41.

 

• Refinement of the oral exposure description in the cyclic siloxane PBPK model for rats and humans: Implications for exposure assessment

By Campbell J L, Andersen M E, van Landingham C, Gentry R, Jensen E, Domoradzki J Y and Clewell H J. Toxicology Letters. Volume 279, Supplement 1, 20 October 2017, Pages 125-135.

 

• Effects of chronic exposure to octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane in the aging female Fischer 344 rat

By Jean P A, Sloter E D and Plotzke K P. Toxicology Letters. Volume 279, Supplement 1, 20 October 2017, Pages 54-74.

 

2016

• Cyclotetrasiloxane, octamethyl-: Human health tier II assessment

IMAP Single Assessment Report 

 

2011

 

• Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane.

By Johnson W Jr, Bergfeld W F, Belsito D V, Hill R A, Klaassen C D, Liebler D C, Marks J G Jr, Shank R C, Slaga T J, Snyder P W and Andersen FA. International Journal of Toxicology (2011). Pages 149S-227S.

 

2010

 

• Opinion on Cyclomethicone Octamethylcyclotetrasiloxane (Cyclotetrasiloxane, D4) and Decamethylcyclopentasiloxane (Cyclopentasiloxane, D5)

By Scientific Committee on Consumer Safety. 22 June 2010. 

 

2007

 

• Modeling of Human Dermal Absorption of Octamethylcyclotetrasiloxane (D4) and Decamethylcyclopentasiloxane (D5)

By Reddy M B, Looney R J, Utell M J, Plotzke K P and Andersen M E. Toxicological Sciences (2007). Volume 99. Pages 422–431.

 

2006

 

• Evaluation of Exposure to D5 for Consumers, Workers, and the General Public

ENVIRON International Corporation. Prepared for Silicone Environmental Health and Safety Council (2006)